Stress hormones in the mother can affect foetal development, a new study says. To test whether high stress levels in pregnant mice had an impact on their offspring, pregnant mice received the natural glucocorticoid corticosterone at different times during pregnancy.
Researchers found that increased levels of glucocorticoid stress hormones in pregnant mice caused the mother to eat more but reduced the ability of the placenta to transport glucose to her foetus.
“The findings show that maternal glucocorticoids regulate foetal nutrition. Higher glucocorticoid hormone levels in the mother can reduce glucose transport across the placenta and lead to a decrease in foetal weight,” explained Owen Vaughan, lead author of the study.
Glucocorticoid levels in pregnant women may determine the specific combination of nutrients received by the foetus and influence the long-term metabolic health of their children as a result.
“This could have implications for women stressed during pregnancy or treated clinically with glucocorticoids, if the mechanisms are similar in humans,” he added. The research showed that under stress, certain genes in the placenta were modified.
One of the genes shown to be altered in the placenta by maternal stress hormones was Redd1.This gene is believed to signal availability of other substances, like oxygen, and to interact with intracellular pathways regulating growth and nutrient uptake in other tissues of the body. “Future studies may prove this molecule is important in the placenta, in linking environmental cues to the nutrition of the foetus,” Vaughan concluded.
The study was published in The Journal of Physiology.